Shapely polysaccharides. The eighth Colworth Medal Lecture

The emergence of protein complexes: quaternary structure, dynamics and allostery. Colworth Medal Lecture.

All proteins require physical interactions with other proteins in order to perform their functions. Most of them oligomerize into homomers, and a vast majority of these homomers interact with other proteins, at least part of the time, forming transient or obligate heteromers. In the present paper, we review the structural, biophysical and evolutionary aspects of these protein interactions. We d...

Colworth Medal lecture. Detection, repair and signalling of DNA double-strand breaks.

Introduction The cells of our bodies are continually under assault by a wide array of DNA-damaging agents. These include reactive oxygen species generated as a consequence of oxidative metabolism, UV light, ionizing radiation and radio-mimetic chemicals. The forms of damage inflicted are many, and range from base adducts, interand intrastrand cross-links, DNA single-strand breaks and DNA double...

Colworth Medal Lecture. Structural studies of reversible protein phosphorylation and protein phosphatases.

Introduction The regulation of cellular processes in response to external stimuli is fundamental to all living processes. It is now recognized that the reversible phosphorylation of proteins is an essential element of the numerous and varied mechanisms that have evolved to communicate these stimuli across a cell’s surface, and subsequently to effect changes in the activities and functions of in...

Insulin, glucagon and the receptor-mediated control of cyclic AMP concentrations in liver. Twenty-second Colworth medal lecture.

Over the past eight years my research interests have been primarily connected with various aspects concerning the molecular mechanisms of action of the receptors for glucagon and insulin. At the time my work started it had only recently been appreciated that integral membrane proteins were mobile entities able to diffuse, freely within the lateral plane of the bilayer. This exciting discovery l...

The Sir David Cuthbertson Medal Lecture 1991